Endocannabinoid System

Not taught in medical school till recent years? The ECS is a major breakthrough and learning more may enable a big leap forward for mankind.
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What is it?

The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors (CBRs), and cannabinoid receptor proteins that are expressed throughout the vertebrate central nervous system (including the brain)

The endocannabinoid system (ECS) is a widespread neuromodulatory system that plays important roles in central nervous system (CNS) development, synaptic plasticity, and the response to endogenous and environmental insults.

The two main receptors of the endocannabinoid system are CB1 and CB2.
Delta-9-tetrahydrocannabinol (THC) can be utilized to break down the fatty acids amide hydrolase, increasing the overall functioning of the endocannabinoid system.
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ECS

The endocannabinoid system (ECS) has emerged as an important neuromodulatory system over the last twenty-five years. Relevant to the topic of this special issue of Biological Psychiatry, perturbations of the ECS are involved in several psychiatric disorders, including schizophrenia.

The CB(1) and CB(2) receptors serve critical roles within the body. Sometimes, however, fatty acid amide hydrolase -- an enzyme -- binds to each receptor type, breaking them down, and limiting the effectiveness of the receptors.
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Cannabinoid receptors

The two main receptors of the endocannabinoid system are CB1 and CB2. Cannabinoid receptors (CB receptors) If eCBs are the messengers, then cannabinoid receptors are the guards posted at the city wall, waiting for the messengers. Receptors sit on cell surfaces, waiting for specific neurotransmitters to bind to them.

Depending on the type of cell the receptor is on, the downstream effect will rapidly impact immunity, sensation, mood, and even consciousness. We have CB receptors throughout our bodies, guarding a wide variety of cell types & responses.
CB1 receptors are essential for a healthy functioning brain and are one of the most common receptors in the entire nervous system. Depending on what region of the brain they are located in, they can be moderators of your memory, mood, motor function, or your perception of pain. These brain receptors are also responsible for the psychoactive properties of cannabis when THC binds to them.
CB2 receptors are most often found on the cells of our immune system. They help moderate inflammation and our immune response to pathogens. If you use cannabis products to combat conditions of an overactive immune system (i.e. arthritis, asthma, allergies, autoimmune disorders or digestive issues like inflammatory bowel disease) you can thank your CB2 receptors.
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Endogenous Cannabinoids

The ECS is comprised of endogenous cannabinoids (endocannabinoids), cannabinoid receptors, and the enzymes responsible for the synthesis and degradation of endocannabinoids (Fig. 1). Each of these components will be introduced in this chapter, with an emphasis on their potential involvement in psychosis.

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The endocannabinoid system

The endocannabinoid system (ECS) has emerged as an important neuromodulatory system over the last twenty-five years. Relevant to the topic of this special issue of Biological Psychiatry, perturbations of the ECS are involved in several psychiatric disorders, including schizophrenia.

The ECS is comprised of endogenous cannabinoids (endocannabinoids), cannabinoid receptors, and the enzymes responsible for the synthesis and degradation of endocannabinoids (Fig. 1). Each of these components will be introduced in this chapter, with an emphasis on their potential involvement in psychosis.

Cannabinoids

What Are Cannabinoids? Cannabinoids are naturally occurring compounds found in the Cannabis sativa plant. Of over 480 different compounds present in the plant, only around 66 are termed cannabinoids.
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About Us

The endocannabinoid system is the reason a plant or plant-based compound is able to cure debilitating diseases, relieve side effects, and so much more. That’s right, our bodies contain cannabinoid receptors.
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