What is it?
The endocannabinoid system (ECS) is a widespread neuromodulatory system that plays important roles in central nervous system (CNS) development, synaptic plasticity, and the response to endogenous and environmental insults.
Depending on the type of cell the receptor is on, the downstream effect will rapidly impact immunity, sensation, mood, and even consciousness. We have CB receptors throughout our bodies, guarding a wide variety of cell types & responses.
The endocannabinoid system
The ECS is comprised of endogenous cannabinoids (endocannabinoids), cannabinoid receptors, and the enzymes responsible for the synthesis and degradation of endocannabinoids (Fig. 1). Each of these components will be introduced in this chapter, with an emphasis on their potential involvement in psychosis.